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Prince Group Publications


Welsh A, Rylands L, Arion V, Prince S, Smith GS, 2019, Synthesis   and   antiproliferative   activity   of benzimidazole-based, trinuclear neutral cyclometallated and cationic, N^N-chelated ruthenium (II) complexes, Dalton Transactions, DOI:10.1039/c9dt03902c.

Khan SF, Damerell V, Omar R, Du Toit M, Khan M, Maranyane H, Mlaza M, Bleloch J, Sahm BDB, Peres J, KN A, Prince S, 2019, The roles and regulation of TBX3 in development and disease, Gene, 726:144223| DOI: 10.1016/j.gene.2019.144223.

Omar R, Cooper A, Maranyane HM, Zerbini L, Prince S, 2019, COL1A2 is a bona fide TBX3 target that mediates its impact on fibrosarcoma and chondrosarcoma cell migration, Cancer Letters, 459:227-239| DOI: 10.1016/j.canlet.2019.06.004

Berg C, Chari S, Jurgaityte K, Laurora A, Naldony M, Pope F, Romano D, Medupe T, Prince S, Ngubane S, Blom B, 2019, Modulation of the solubility properties of arene ruthenium complexes bearing stannyl ligands as potential anti-cancer agents, Journal of Organometallic Chemistry, 891:12-19| DOI: 10.1016/j.jorganchem.2019.04.002.

Nel M, Prince S, Heckmann J, 2019, Profiling of patient-specific myocytes identifies altered gene expression in the ophthalmoplegic subphenotype of myasthenia gravis. Orphanet Journal of Rare Diseases, 14:24|DOI: 10.1186/s13023-019-1003-y.

Bleloch J, du Toit A, Gibhard L, Kimani S, Ballim R, Lee M, Blanckenberg A, Mapolie D, Wiesner L, Loos B, Prince S, 2019, The palladacycle complex AJ-5 induces apoptotic cell death while reducing autophagic flux in rhabdomyosarcoma cells, Cell Death Discovery, 5:60| DOI: 10.1038/s41420-019-0139-9.


Jacobs B-A, Chetty A, Horsnell W, Schäfer G, Prince S, Smith KA, 2018 Hookworm exposure decreases the migration and human papillomavirus internalisation of cervical cancer cells. Scientific Reports, 8:11547 | DOI:10.1038/s41598-018-30058-9

Cassells I, Stringer T, Hutton A, Prince S, Smith Greg, 2018 Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions. Journal of Biological Inorganic Chemistry, 23:763–774. https://doi.org/10.1007/s00775-018-1567-3

Davis T, van Niekerk G, Peres J, Prince S, Loos B, Engelbrecht A-M, 2018 Doxorubicin resistance in breast cancer: A novel role for the human protein AHNAK. Biochemical Pharmacology, 148:174-183. DOI: 10.1016/j.bcp.2018.01.012

Jivan R, Peres J, Damelin LH, Wadee R, Veale RB, Prince S, Mavri-Damelin D, 2018 Disulfiram with or without metformin inhibits oesophageal squamous cell carcinoma in vivo. Cancer Letters, 417:1-10. https://doi.org/10.1016/j.canlet.2017.12.026

Zhu B, Chen S, Wang H, Yin C, Han C, Peng C, Liu Z-Q, Wan L, Zhang X, Zhang J, Lian C, Ma P, Xu X, Xu Z-X, Prince S, Wang T, Gao X, Shi Y, Dali L, Liu M, Wei W, Wei Z, Pan J, Wang Y, Xuan Z, Hess J, Hayward N, Goding C, Chen X, Zhou J , Cui R, 2018 The protective role of DOT1L in UV-induced melanomagenesis. Nature Communications, 9:259. DOI: 10.1038/s41467-017-02687-7


Nel M, Buys J-M, Wearne N, Botha FCJ, Prince S, Heckmann J, 2017 The functionality of African-specific variants in the TGFB1 regulatory region and their potential role in HIVAN. Clinical and Experimental Nephrologyhttps://doi.org/10.1007/s10157-017-1516-4

Blanckenberg A, van Niekerk A, Aliwaini S, Kimani SW, Neumann A, Prince S, Mapolie SF, 2017 Preparation, characterization and evaluation of novel 1,3,5-triaza-7-phosphaadamantane (PTA)-based palladacycles as anti-cancer agents. Journal of Organometallic Chemistry, 851:68-78. https://doi.org/10.1016/j.jorganchem.2017.09.005

Peres J, Maliepaard EM, Rambow F, Larue L, Prince S, 2017 Replacement of the tumour suppressor, miR-137, inhibits malignant melanoma migration by targetting the TBX3 transcription factorCancer Letters, DOI: 10.1016/j.canlet.2017.07.018.

Mynhardt C, Damelin LH, Jivan R, Peres J, Prince S, Veale RB and Mavri-Damelin D, 2017 Metformin-induced alterations in nucleotide metabolism cause 5-fluorouracil resistance but gemcitabine susceptibility in oesophageal squamous cell carcinomaJournal of Cellular Biochemistry, DOI:10.1002/jcb.26291.

Matsheku A, Chen M, Jordaan S, Prince S, Smith G, Makhubela B, 2017 Acridine-containing RuII, OsII, RhIII and IrIII Half-Sandwich Complexes: Synthesis, Structure and Antiproliferative ActivityApplied Organometallic Chemistry, DOI:10.1002/aoc.3852.

Willmer T, Cooper A, Peres J, Omar R, Prince S, 2017 The T-Box transcription factor 3 in development and cancer.BioScience Trends, DOI: http://doi.org/10.5582/bst.2017.01043.

Bleloch JS, Ballim RD, Kimani S, Parkes J, Panieri E, Willmer T, Prince S, 2017 Managing sarcoma: Where have we come from and where are we going? Therapeutic Advances in Medical Oncology, In press.


Klionsky D et al., 2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).AUTOPHAGY, 12:1, 1–222. http://dx.doi.org/10.1080/15548627.2015.1100356.

MK H, Prince S, Mohan AM, Krishnan KV, Arikketh D, 2016 Involvement of Notch4 in promoting metastasis in human oral squamous cell carcinomaLife Sciences 156, 38-46.

Willmer T, Hare S, Peres J, Prince S, 2016 The T-box transcription factor TBX3 drives proliferation by direct repression of the p21WAF1 cyclin-dependent kinase inhibitor. Cell Division 11:6 DOI 10.1186/s13008-016-0019-0 URL:http://www.celldiv.com/content/11/1/6.

Aliwaini S, Bleloch J, Kimani S, Prince S, 2016 Induction of autophagy and apoptosis in melanoma treated with palladacycle complexes. Elsevier Publishing Company nine-volume series discussing AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging Vol 10 edited by M.A. Hayat (Invited).

Willmer T, Cooper A, Sims D, Govender D, Prince S, 2016 The T-box transcription factor 3 is a promising biomarker and a key regulator of the oncogenic phenotype of a diverse range of sarcoma subtypesOncogenesis 5, e199; doi:10.1038/oncsis.2016.11.


Nel M, Buys J-M, Rautenbach R, Mowla S, Prince S, Heckmann JM, 2015 The African−387 C>T TGFB1 variant is functional and associates with the ophthalmoplegic complication in juvenile myasthenia gravisJournal of Human Genetics, (3 December 2015) DOI:10.1038/jhg.2015.146

Willmer T, Peres J, Mowla S, Abrahams A, Prince S, 2015 The T-Box factor TBX3 is important in S-phase and is regulated by c-Myc and cyclin ACDK2Cell Cycle, 14:19, 3173-3183. DOI: 10.1080/15384101.2015.1080398.

Prince S, Mapolie S, Blanckenberg A, 2015 Palladium-Based Anti-Cancer TherapeuticsEncyclopedia of Cancer, DOI 10.1007/978-3-642-27841-9_7085-1 (Invited)

Aliwaini S, Peres J, Kröger WL, Blanckenberg A, de la Mare J, Edkins AL, Mapolie S, Prince S, 2015 The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cellsCancer Letters, 357, 206-218. doi:10.1016/j.canlet.2014.11.027.

Peres J, Mowla S, Prince S, 2015 The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis.Oncotarget, 6 (3), 1821-1833.


Li J, Ballim RD, Rodriguez M, Cui R, Goding CR, Teng H, Prince S, 2014 The Anti-proliferative Function of the TGF-β1 Signalling Pathway Involves the Repression of the Oncogenic TBX2 by its Homologue TBX3Journal of Biological Chemistry, 289, 35633-35643 DOI:10.1074/jbc.M114.596411.

Wansleben S, Peres J, Hare S, Goding CR, Prince S, 2014 T-box transcription factors in cancer biologyBBA - Reviews on Cancer, 1846, 380-391. doi:10.1016/j.bbcan.2014.08.004

Bouafia A, Corre S, Gilot D, Mouchet N, Prince S, Galibert M-D, 2014 p53 requires the stress sensor USF1 to direct appropriate cell fate decisionsPLoS Genetics, 2014; 10(5):e1004309. 

Auret J, Abrahams A, Prince S, Heckmann JM, 2014 The Effects of Prednisone and Steroid-sparing agents on Decay Accelerating Factor (CD55) expression: implications in Myasthenia Gravis Neuromuscular DisordersNeuromuscular Disorders, 24, 499-508 DOI: 0.1016/j.nmd.2014.02.010.


Peres J, Prince S, 2013 The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion.Molecular cancer, 12:117.DOI: 10.1186/1476-4598-12-117 URL: http://www.molecular-cancer.com/content/12/1/117.

Aliwaini S, Blanckenberg A, Swarts AJ, Mapolie S, Prince S, 2013 A novel binuclear palladacycle complex inhibits melanoma growth in vitro and in vivo through apoptosis and autophagyBiochemical Pharmacology 86, 1650–1663.

Wansleben S, Davis E, Peres J, Prince S, 2013 A novel role for the anti-senescence factor TBX2 in DNA repair and cisplatin resistance. Cell Death and Disease 4, e846 doi:10.1038/cddis.2013.365.

Li J, Weinberg MS, Zerbini L, Prince S, 2013 The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signalling pathway. Molecular Biology of the Cell, 24(22):3569-76. doi: 10.1091/mbc.E13-05-0273. Epub 2013 Sep 11. www.molbiolcell.org/content/early/2013/09/09/mbc.E13-05-0273.full.pdf.

Ballim RD, Prince S, 2013 TBX3 (T-box 3)Atlas Genet Cytogenet Oncol Haematol. URL : http://AtlasGeneticsOncology.org/Genes/TBX3ID42486ch12q24.htmlAtlas of Genetics and Cytogenetics in Oncology and Haematology (Invited)


Abrahams Y, Laguette M-J, Prince S, Collins M, 2012 Polymorphisms within the COL5A1 3’-UTR that alters mRNA structure and the MIR608 gene are associated with Achilles tendinopathy. Annals of Human Genetics, 77(3):204-214.

Ballim RD, Mendelsohn C, Papaioannou VE, Prince S, 2012 The ulnar-mammary syndrome gene, Tbx3, is a direct target of the retinoic acid signaling pathway, which regulates its expression during mouse limb development. Molecular Biology of the Cell, 23:2362-2372.

Baron Y, Corre S, Mouchet N, Vaulont S, Prince S, Galibert M-D, 2012 USF-1 Is Critical for Maintaining Genome Integrity in Response to UV-Induced DNA PhotolesionsPLoS Genetics, 8(1):e1002470.


Smith J, Mowla S, Prince S, 2011 Basal Transcription of the human TBX3 gene, a key developmental regulator which is overexpressed in several cancers, requires functional NF-Y and Sp1 sitesGene, 486(1-2): 41-6.

Laguette M-J, Abrahams Y, Prince S, Collins M, 2011 Sequence Variants within the 3' UTR of the COL5A1 gene alters mRNA stability: Implications for musculoskeletal soft tissue injuriesMatrix Biology, 30(5-6):338-45.


Mowla S, Pinnock R, Leaner V, Goding CR, Prince S, 2010 PMA-induced upregulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migrationBiochemical Journal, 433:145-153.

Pandor A, Ramesar R, Prince S, 2010 Cell-Specific Differences in the Processing of the R14W CAIV Mutant Associated With Retinitis Pigmentosa 17Journal of Cellular Biochemistry, 111:735–741.

Peres J, Davis E, Mowla S, Bennett DC, Li JA, Wansleben S, Prince S, 2010 The Highly Homologous T-Box Transcription Factors, TBX2 and TBX3, Have Distinct Roles in the Oncogenic ProcessGenes and Cancer, 1(3):272-282.

Abrahams A, Parker MI, Prince S, 2010 The T-box transcription factor Tbx2: It's role in development and possible implication in cancerIUBMB Life, 62(2): 92–102.

Heckmann J, Uwimpuhwe H, Ballo R, Kaur M, Bajic VB, Prince S, 2010 A functional SNP in the regulatory region of the decay-accelerating factor gene associates with extraocular muscle pareses in myasthenia gravis. Genes and Immunity, 11(1): 1 – 10.


Teng H, Ballim RD, Mowla S, Prince S, 2009 Phosphorylation of histone H3 by Protein Kinase C signalling plays a critical role in the regulation of the developmentally important TBX2 geneJournal of Biological Chemistry, 284:26368-26376.


Davis E, Teng H, Bilican B, Parker MI, Liu B, Carriera S, Goding C, Prince S, 2008 Ectopic TBX2 expression results in polyploidy and cisplatin resistanceOncogene, 27, 976–984.

Abrahams A, Mowla S, Parker MI, Goding C, Prince S, 2008 UV-mediated Regulation of the Anti-senescence Factor Tbx2.Journal of Biological Chemistry, 283(4), 2223-2230.

Teng H, Parker MI, Prince S, 2008 Functional characterization of cis-acting elements involved in basal transcription of the human Tbx2 gene:  A new insight into the role of Sp1 in transcriptional regulation. Gene, 423(1): 8-13.


Teng H, Davis E, Abrahams A, Mowla S, Parker MI, Prince S, 2007 A role for Tbx2 in the regulation of the 2(1) collagen gene in human fibroblasts. Journal of Cellular Biochemistry, 102(3), 618-625.


Prince S, Carreira S, Vans K, Abrahams A, Goding C, 2004 Tbx2 directly represses the expression of the p21WAF1 cyclin-dependent kinase inhibitorCancer Research, 64, 1669-1674.